MISSED DOSE If you miss a dose, take it as soon as remembered;Severe hepatotoxicity associated with the combination of spiramycin plus metronidazole Hussein R (1), ElHalabi M, Ghaith O, Jurdi N, Azar C, Mansour N, Sharara AI (1)Division of Gastroenterology, Department of Medicine, American University of Beirut Medical Center, Beirut, Lebanon Druginduced liver injury (DILI) is a leading cause of acuteSpiramycin Spiramycin is a macrolide antibiotic that is given to pregnant women infected with Toxoplasma gondii It reduced placenta infection by 60 percent The recommended dose is 3 g/day, every 8 hours Spiramycin is administered from when the infection is diagnosed until delivery MartinRabadan et al (1999)
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